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diazepam for dogsDiazepam should not be diluted with parenteral fluids. One exception is when it is considered essential to administer it in a large volume of fluids (see i.v. Infusion under Dosage).
Abrupt cessation of large doses of diazepam after prolonged periods may precipitate acute withdrawal symptoms and, in these cases, the drug should be discontinued gradually. Caution should be exercised when it is considered necessary to administer diazepam to addiction-prone individuals.
Adsorption onto plastic drip tubing causes an initial significant and variable reduction (up to 40% or more) of delivered diazepam concentration which then gradually rises over the next few hours. The drip rate should be frequently titrated against the patient's condition.